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Andarine is designed specifically for the treatment of muscle atrophy, perfectly copes with the suppression of destructive catabolism, and is well tolerated in healthy volunteers (15-17), although further research is needed to verify its efficacy in individuals with metabolic syndrome. In contrast, Rizan et al (18), recently reported that dietary restriction results in significantly superior improvements in aerobic capacity and mitochondrial biogenesis in mice on standard-high-fat diet for 7 years. It is worth noting that the mice fed standard-high-fat diet demonstrated a greater loss of body weight compared with those fed the Rizan diet, but this is likely attributable to the fact that dietary restriction, despite maintaining a normal caloric intake, caused a significant reduction in body weight and decreased adiposity compared with standard-high-fat environment. Rizan et al demonstrated a dramatic reduction in muscle damage and a preservation of mitochondrial biogenesis in their mouse muscle models with diet with low calories. As for the study by Schoenfeld and colleagues (19),